Research Keyword computational methods
Steven George
Cardiopulmonary Transport and Tissue Remodeling Laboratory
Director
The Edwards Lifesciences Center for Advanced Cardiovascular Technology
Lab: 2121 Engineering Hall
Office: 2420 Engineering Hall
Office: 2420 Engineering Hall
Professor
Biomedical Engineering
Professor (Joint Appointment)
Chemical Engineering and Materials Science
Dr. George's work focuses on understanding the biology and physiology of the cardiopulmonary system. The approach integrates experimental observations and mathematical modeling. Within this context, he is pursuing two overarching areas of research, both of which combine cell, tissue, and whole organ studies: 1) prevascularization of implantable thick tissue constructs, 2) nitric oxide metabolism and 3) wound healing and tissue remodeling.
Dr. George and his group are working with Dr. Hughes in the School of Biological Sciences to prevascularize an implantable tissue construct with a network of mature interconnected capillaries that can rapidly anastomose with a host upon implantation. This project addresses a fundamental need in the field of tissue engineering – the creation of implantable tissues whose dimensions exceed the limit provided by diffusive transport alone. His lab is also working toward an understanding of what changes in the local biochemical environment affect nitric oxide exchange and tissue remodeling dynamics at the cellular and whole-organ level. The projects involve an understanding of the fluid mechanics of the bifurcating tubes, mass transfer coefficients, and biomechanics. Additional information on these and other projects can be found on his lab website.
Dr. George and his group are working with Dr. Hughes in the School of Biological Sciences to prevascularize an implantable tissue construct with a network of mature interconnected capillaries that can rapidly anastomose with a host upon implantation. This project addresses a fundamental need in the field of tissue engineering – the creation of implantable tissues whose dimensions exceed the limit provided by diffusive transport alone. His lab is also working toward an understanding of what changes in the local biochemical environment affect nitric oxide exchange and tissue remodeling dynamics at the cellular and whole-organ level. The projects involve an understanding of the fluid mechanics of the bifurcating tubes, mass transfer coefficients, and biomechanics. Additional information on these and other projects can be found on his lab website.
William Sirignano
http://mae.eng.uci.edu/Faculty/was/index.html
The Henry Samueli Endowed Chair in Engineering and Professor
Mechanical and Aerospace Engineering
Office: EG 3202
Lab: EG 3101
Lab: EG 3101
Dr. Sirignano is interested in combustion theory and computational methods, fluid dynamics, multiphase flows, and propulsion and power.
His current research activities address the problems of the vaporization and burning of liquid fuels in very small volumes, turbulence-droplet interactions, distortion and breakup of thin liquid streams, flame spread across liquid fuel pools, and a study of combustion in high speed flows. The applications of the research include miniaturization of combustors, spray technologies, fire safety, and a new high-performance technology for combustion in the turbine stages of a gas-turbine engine.
Dr. Sirignano leads the Combustion, Fluid Dynamics and Propulsion Group and is the director of the Spray and Droplet Science and Technology Center at UCI.
